Search results for " ovarian neoplasms"

showing 10 items of 20 documents

Laparoscopic Management of Ovarian Cancer Patients With Localized Carcinomatosis and Lymph Node Metastases: Results of a Retrospective Multi-institut…

2016

Abstract Study Objective To investigate the feasibility and safety of laparoscopic cytoreduction in ovarian cancer patients with localized carcinomatosis or lymph node involvement. Design Retrospective cohort study (Canadian Task Force classification II-2). Setting Multi-institutional study performed in 6 referral gynecologic oncology units. Patients Between June 2005 and December 2014, preoperatively presumed early-stage ovarian cancer patients, who accidentally revealed localized carcinomatosis or lymph node involvement at laparoscopic evaluation or at postoperative pathological examination managed by the laparoscopic approach. Interventions All patients with limited carcinomatosis and/or…

Adultmedicine.medical_specialtymedicine.medical_treatmentLaparoscopic cytoreduction; Laparoscopy; Minimally invasive surgery; Ovarian cancer; Adult; Aged; Aged 80 and over; Carcinoma; Cytoreduction Surgical Procedures; Disease-Free Survival; Feasibility Studies; Female; Humans; Laparoscopy; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence Local; Ovarian Neoplasms; Retrospective Studies; Young AdultGynecologic oncologyDisease-Free SurvivalLaparoscopic cytoreduction Laparoscopy Minimally invasive surgery Ovarian cancerYoung Adult03 medical and health sciences0302 clinical medicineMinimally invasive surgeryOvarian cancerCytoreduction Surgical Procedures80 and overmedicineCarcinomaHumansLymph nodeSurvival rateAgedRetrospective StudiesAged 80 and overOvarian Neoplasms030219 obstetrics & reproductive medicinebusiness.industryCarcinomaObstetrics and GynecologyRetrospective cohort studyCytoreduction Surgical ProceduresMiddle Agedmedicine.diseaseSurgeryNeoplasm Recurrencemedicine.anatomical_structureLocalLaparoscopic cytoreductionLymphatic Metastasis030220 oncology & carcinogenesisFeasibility StudiesFemaleLaparoscopyLymphadenectomyLymph NodesNeoplasm Recurrence LocalbusinessOvarian cancerJournal of Minimally Invasive Gynecology
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Minimally invasive interval debulking surgery in ovarian neoplasm (MISSION trial–NCT02324595): a feasibility study

2016

Background Laparoscopy has acquired an increasing role in the management of ovarian cancer. Laparoscopic cytoreduction could represent a new frontier for selected patients after neoadjuvant chemotherapy (NACT). Objective We sought to assess feasibility and early complication rate of minimally invasive (MI) interval debulking surgery (IDS) in stage III-IV epithelial ovarian cancer (EOC) patients after NACT. Study Design This is a phase II multicentric study in advanced EOC cases with clinical complete response after NACT, according to Gynecologic Cancer Intergroup and Response Evaluation Criteria In Solid Tumors criteria. Institutional review board approval was obtained and all patients sign…

Neoplasm Residualmedicine.medical_treatmentchemotherapyresidual0302 clinical medicine80 and overMedicineminimally invasive surgeryAged 80 and overOvarian Neoplasms030219 obstetrics & reproductive medicineadvanced ovarian cancerMedicine (all)Obstetrics and GynecologyCytoreduction Surgical ProceduresBowel resectionMiddle AgedDebulkinglaparoscopic cytoreductionNeoadjuvant TherapyIntestinesChemotherapy AdjuvantResponse Evaluation Criteria in Solid Tumors030220 oncology & carcinogenesisinterval debulking surgeryFemaleMedian bodyPeritoneumOmentumneoadjuvant chemotherapyAdultmedicine.medical_specialtyOvariectomyadvanced ovarian cancer; interval debulking surgery; laparoscopic cytoreduction; minimally invasive surgery; neoadjuvant chemotherapy; quality of life; Adult; Aged; Aged 80 and over; Appendectomy; Chemotherapy Adjuvant; Fallopian Tubes; Feasibility Studies; Female; Humans; Hysterectomy; Intestines; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence Local; Neoplasm Residual; Omentum; Ovarian Neoplasms; Ovariectomy; Peritoneum; Cytoreduction Surgical Procedures; Laparoscopy; Medicine (all); Obstetrics and GynecologyHysterectomy03 medical and health sciencesadjuvantlocalAppendectomyHumansSurvival rateFallopian TubesAgedHysterectomybusiness.industryAdvanced ovarian cancer interval debulking surgery laparoscopic cytoreduction minimally invasive surgery neoadjuvant chemotherapy quality of life adult aged 80 and over appendectomy chemotherapy adjuvant fallopian tubes feasibility studies female humans hysterectomy intestines middle aged neoadjuvant therapy neoplasm recurrence local neoplasm residual omentum ovarian neoplasms ovariectomy peritoneum cytoreduction surgical procedures laparoscopyPerioperativeneoplasm recurrenceSurgerySettore MED/40 - GINECOLOGIA E OSTETRICIAquality of lifeFeasibility StudiesLaparoscopyLymphadenectomyNeoplasm Recurrence LocalbusinessneoplasmAmerican Journal of Obstetrics and Gynecology
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Implementation of preventive and predictive BRCA testing in patients with breast, ovarian, pancreatic, and prostate cancer: a position paper of Itali…

2022

Constitutional BRCA1/BRCA2 pathogenic or likely pathogenic variants (PVs) are associated with an increased risk for developing breast and ovarian cancers. Current evidence indicates that BRCA1/2 PVs are also associated with pancreatic cancer, and that BRCA2 PVs are associated with prostate cancer risk. The identification of carriers of constitutional PVs in the BRCA1/2 genes allows the implementation of individual and family prevention pathways, through validated screening programs and risk-reducing strategies. According to the relevant and increasing therapeutic predictive implications, the inclusion of BRCA testing in the routine management of patients with breast, ovarian, pancreatic and…

Societies ScientificMaleOvarian NeoplasmsCancer Researchgenetic counselingBRCABRCA testing; BRCA-related cancer; BRCA1; BRCA2; PARP inhibitors; genetic counseling; pancreatic ductal adenocarcinomaProstatic Neoplasmspancreatic ductal adenocarcinomaScientificSettore MED/03 - GENETICA MEDICABRCA testing; BRCA-related cancer; BRCA1; BRCA2; PARP inhibitors; genetic counseling; pancreatic ductal adenocarcinoma; Female; Humans; Italy; Male; Societies Scientific; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic NeoplasmsBRCA1BRCA2BRCA-related cancerPancreatic NeoplasmsBRCA testingPARP inhibitorOncologyItalyHumansFemaleSocietiesPARP inhibitors
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Influence of Intraperitoneal Dissemination Assessed by Laparoscopy on Prognosis of Advanced Ovarian Cancer: An Exploratory Analysis of a Single-Insti…

2014

Purpose: The aim of this study was to investigate whether preoperative laparoscopic evaluation of the dissemination of disease may have an independent impact on survival in advanced epithelial ovarian cancer (AEOC).Methods: All AEOC women were submitted to staging laparoscopy before receiving primary debulking surgery (PDS) or neoadjuvant chemotherapy (NACT). All study women received a laparoscopic score (predictive index value [PIV]) and were stratified into three groups based on volume of disease: high tumor load (HTL) for PIV ≥8, intermediate tumor load (ITL) for PIV equal to 6 and 4, and low tumor load (LTL) for PIV 1 cm in 15 cases (9.1 %). When stratifying the whole population accordi…

AdultOncologymedicine.medical_specialtyNeoplasm ResidualAdult; Aged; Aged; 80 and over; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Laparoscopy; Middle Aged; Neoplasm Staging; Neoplasm; Residual; Ovarian Neoplasms; Peritoneal Neoplasms; Prognosis; Retrospective Studies; Survival Rate; Tumor BurdenPopulationlaparoscopySurgical oncologyInternal medicineHumansMedicineeducationLaparoscopySurvival ratePeritoneal NeoplasmsAgedNeoplasm StagingRetrospective StudiesAged 80 and overOvarian Neoplasmseducation.field_of_studymedicine.diagnostic_testPerformance statusbusiness.industryMedicine (all)Retrospective cohort studyMiddle AgedPrognosismedicine.diseaseDebulkingCombined Modality TherapyTumor BurdenSurvival Rateovarian cancerSettore MED/40 - GINECOLOGIA E OSTETRICIAOncologyFemaleSurgerybusinessOvarian cancerFollow-Up StudiesAnnals of Surgical Oncology
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Laparoscopic surgical management of localized recurrent ovarian cancer: a single-institution experience

2014

Background: Optimally, secondary cytoreduction is acknowledged as a valid option in terms of oncologic outcome for patients with platinum-sensitive recurrent ovarian cancer. In cases of localized relapse, a laparoscopic approach has been attempted at various institutions, but studies on its role for this subset of patients still are limited. This report describes the authors' experience using laparoscopic secondary cytoreduction for patients with localized recurrent ovarian cancer. The results from a retrospective analysis of a prospective case series are reported. Methods: Between October 2011 and May 2013, 29 patients with localized recurrent ovarian cancer were selected for a laparoscopi…

Secondary cytoreductionmedicine.medical_treatmentTissue AdhesionsPostoperative ComplicationsLaparotomyLaparoscopyOvarian Neoplasmsmedicine.diagnostic_testMedicine (all)Middle Agedovarian cancerChemotherapy AdjuvantLymphatic MetastasisFemaleAdult; Aged; Antineoplastic Agents; Carcinoma; Chemotherapy; Adjuvant; Disease-Free Survival; Female; Follow-Up Studies; Humans; Laparoscopy; Laparotomy; Length of Stay; Lymph Node Excision; Lymphatic Metastasis; Middle Aged; Monitoring; Intraoperative; Neoplasm Recurrence; Local; Neoplasm Staging; Operative Time; Ovarian Neoplasms; Postoperative Complications; Retrospective Studies; Tissue AdhesionsAdultmedicine.medical_specialtyRecurrent ovarian cancer; Laparoscopy; Secondary cytoreductionOperative TimeAntineoplastic AgentsDisease-Free SurvivalLaparoscopicMonitoring IntraoperativeInternal medicineCarcinomamedicineHumansAgedNeoplasm StagingRetrospective StudiesLaparotomybusiness.industryGeneral surgeryCarcinomaRetrospective cohort studyLength of StayHepatologymedicine.diseaseSurgerySettore MED/40 - GINECOLOGIA E OSTETRICIARecurrent Ovarian CancerLymph Node ExcisionSurgeryLaparoscopyNeoplasm Recurrence LocalRecurrent ovarian cancerOvarian cancerbusinessFollow-Up StudiesAbdominal surgery
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Carboplatin and pegylated liposomal doxorubicin for advanced ovarian cancer. Preliminary activity results of the MITO-2 phase III trial

2008

<i>Background:</i> Based on the efficacy of pegylated liposomal doxorubicin (PLD) in relapsed ovarian cancer, we are conducting a phase III study comparing carboplatin plus either paclitaxel or PLD as first-line therapy in advanced ovarian cancer. Because of limited phase I and II data on PLD plus carboplatin in this setting, we conducted an interim activity analysis. <i>Patients and Methods:</i> Patients with stage 1c-IV epithelial ovarian cancer were randomized to carboplatin AUC 5 plus either paclitaxel 175 mg/m<sup>2</sup> or PLD 30 mg/m<sup>2</sup> every 3 weeks for 6 cycles. The interim activity analysis was planned according to a single…

Oncologyarea under curveCancer Researchendocrine system diseasesmedicine.medical_treatmentneoplasmspolyethylene glycolsantibioticsPegylated Liposomal Doxorubicinsurvival analysischemistry.chemical_compoundpaclitaxelmiddle agedantineoplastic agentsNeoplasms Glandular and EpithelialhumansanthracyclinesAntibiotics AntineoplasticadultGeneral Medicineovarian neoplasmsfemale genital diseases and pregnancy complicationsagedovarian cancerfemaleOncologyPaclitaxelcarboplatinlipids (amino acids peptides and proteins)Anthracyclinesmedicine.drugmedicine.medical_specialtyantineoplasticantineoplastic combined chemotherapy protocolsglandular and epithelialdoxorubicinpegylated liposomal doxorubicinInternal medicineanthracyclines; carboplatin; ovarian cancer; paclitaxel; pegylated liposomal doxorubicin; adult; aged; antibiotics antineoplastic; antineoplastic agents; antineoplastic combined chemotherapy protocols; area under curve; carboplatin; doxorubicin; female; humans; middle aged; neoplasm staging; neoplasms glandular and epithelial; ovarian neoplasms; paclitaxel; polyethylene glycols; survival analysis; treatment outcomemedicineDoxorubicinneoplasm stagingAdvanced ovarian cancerChemotherapybusiness.industryCancermedicine.diseaseCarboplatinEndocrinologychemistrytreatment outcomebusinessOvarian cancer
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Atypical presentation of anti-N-methyl-D-aspartate receptor encephalitis: two case reports

2017

Abstract Background Anti-N-methyl-D-aspartate receptor encephalitis is a rare autoimmune disease characterized by severe neurological and psychiatric symptoms and a difficult diagnosis. The disease is often secondary to a neoplastic lesion, seldom diagnosed years later. Psychiatric symptoms are prevalent in adults; neurologic symptoms are more evident in children, who typically present primarily with neurological symptoms. To the best of our knowledge, the association with juvenile idiopathic arthritis has not been described. Case presentation We report the cases of two caucasian girls with an atypical presentation. The first patient was an 8-year-old girl with normal psychomotor developmen…

PediatricsPathologyChoreiform movementAnti-Inflammatory AgentsArthritislcsh:MedicineCase ReportDisease0302 clinical medicinePrednisoneChildOvarian Neoplasms030219 obstetrics & reproductive medicineMedicine (all)Remission InductionTeratomaImmunoglobulins IntravenousGeneral MedicineMagnetic Resonance ImagingTreatment OutcomeMethylprednisoloneFemaleHip JointTeratomamedicine.symptomEncephalitismedicine.drugmedicine.medical_specialtyAdolescentAnti-N-methyl-D-aspartate receptor encephalitis; Chorea; Juvenile idiopathic arthritis; Psychiatric symptoms; Speech disorders; Teratoma; Medicine (all)Methylprednisolone03 medical and health sciencesJuvenile idiopathic arthritiChoreaPsychiatric symptomsmedicineHumansImmunologic FactorsAnti-N-methyl-D-aspartate receptor encephalitis; Chorea; Juvenile idiopathic arthritis; Psychiatric symptoms; Speech disorders; TeratomaAnti-N-methyl-D-aspartate receptor encephalitis; Chorea; Juvenile idiopathic arthritis; Psychiatric symptoms; Speech disorders; Teratoma; Adolescent; Anti-Inflammatory Agents; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Arthritis Infectious; Child; Female; Hip Joint; Humans; Immunoglobulins Intravenous; Immunologic Factors; Magnetic Resonance Imaging; Methylprednisolone; Ovarian Neoplasms; Remission Induction; Teratoma; Treatment Outcome; Medicine (all)Speech disorderSpeech disordersArthritis InfectiousPsychiatric symptombusiness.industrylcsh:RChoreaJuvenile idiopathic arthritismedicine.diseaseAnti-N-methyl-D-aspartate receptor encephalitisbusiness030217 neurology & neurosurgeryAnti-N-methyl-D-aspartate receptor encephaliti
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The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2).

2016

OBJECTIVE: Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival. METHODS: The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995-2009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included. We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology. RESULTS: During 2005-2009, type II epithelial tumours…

Epidemiology; Histology; Morphology; Ovarain cancer; Worldwide0301 basic medicineOncologyPathologyendocrine system diseasesEpidemiologySex Cord-Gonadal Stromal TumorsCarcinoma Ovarian Epithelial0302 clinical medicineNeoplasmsEpidemiologyNeoplasms Glandular and EpithelialOvarian Neoplasmseducation.field_of_studyEpidemiology; Histology; Morphology; Ovarain cancer; Worldwide; Adolescent; Adult; Aged; Female; Humans; Middle Aged; Neoplasms Germ Cell and Embryonal; Neoplasms Glandular and Epithelial; Ovarian Neoplasms; Sex Cord-Gonadal Stromal Tumors; Oncology; Obstetrics and GynecologyGlandular and EpithelialObstetrics and GynecologyMiddle AgedNeoplasms Germ Cell and Embryonalfemale genital diseases and pregnancy complicationsTransitional cell carcinomaOncology030220 oncology & carcinogenesisClear cell carcinomaFemaleWorldwideHumanMorphologyAdultendocrine systemmedicine.medical_specialtyHistologyAdolescentEpidemiology ; Histology ; Morphology ; Ovarain cancer ; WorldwidePopulationSocio-culturale03 medical and health sciencesInternal medicinemedicineHumansSex Cord-Gonadal Stromal TumorseducationAgedMixed tumorbusiness.industryOvarian NeoplasmSex Cord-Gonadal Stromal TumorHistologymedicine.diseaseOvarain cancerEpidemiology; Histology; Morphology; Ovarain cancer; Worldwide;030104 developmental biologyGerm Cell and EmbryonalOvarian cancerbusinessGynecologic oncology
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Sentinel-node biopsy in early stage ovarian cancer: a prospective multicentre study (SELLY)

2019

BackgroundSystematic para-aortic and bilateral pelvic lymphadenectomy is included in the standard comprehensive surgical staging in presumed early epithelial ovarian cancer. No prospective randomized evidence suggests it has potential therapeutic value, and related morbidity is not negligible.Primary Objective(s)To assess sensitivity, safety, and feasibility of the sentinel lymph node technique in identifying the presence of lymph node metastases in patients with early stage epithelial ovarian cancer.Study HypothesisSentinel lymph node detection with indocyanine green can accurately predict nodal status in a cohort of women with early stage epithelial ovarian cancer.Trial DesignThe SELLY tr…

medicine.medical_specialtyearly ovarian cancermedicine.medical_treatmentearly ovarian cancer; indocyanine green (ICG); laparoscopy; lymphadenectomy; minimally-invasive surgery; sentinel node; Carcinoma Ovarian Epithelial; Cohort Studies; Female; Humans; Lymph Nodes; Lymphatic Metastasis; Neoplasm Staging; Ovarian Neoplasms; Prospective Studies; Sensitivity and Specificity; Sentinel Lymph Node; Sentinel Lymph Node BiopsySentinel lymph nodelaparoscopyCarcinoma Ovarian EpithelialSensitivity and SpecificityCohort Studiesindocyanine green (ICG)Ovarian EpithelialBiopsymedicineClinical endpointHumansProspective StudiesStage (cooking)Lymph nodeNeoplasm StagingOvarian Neoplasmsmedicine.diagnostic_testbusiness.industrySentinel Lymph Node BiopsyCarcinomaObstetrics and GynecologySentinel nodemedicine.diseaseearly ovarian cancer; indocyanine green (ICG); laparoscopy; lymphadenectomy; minimally-invasive surgery; sentinel nodeminimally-invasive surgerymedicine.anatomical_structureSettore MED/40 - GINECOLOGIA E OSTETRICIAOncologysentinel nodeLymphatic MetastasislymphadenectomyLymphadenectomyFemaleRadiologyLymph NodesSentinel Lymph NodebusinessOvarian cancer
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Role of robotic surgery in ovarian malignancy

2017

As part of minimally invasive surgery, robotic-assisted approach is becoming increasingly popular in gynecologic oncology. It has been shown to be effective and feasible for staging and treating endometrial and cervical cancer, but its role in the context of primary and recurrent ovarian cancers is presently debated. Scanty data are available in the literature, and the level of evidence supporting its use in ovarian cancer is quite low. However, from a retrospective case-control series, robotic surgery seems to be safe and feasible for early-stage ovarian cancer. Its use in treating patients with advanced-stage or relapsed ovarian cancer is still highly controversial, suggesting the choice …

Oncologymedicine.medical_specialtyPopulationContext (language use)robotic surgery ovarian cancerGynecologic oncologygynecologic oncology03 medical and health sciencesGynecologic Surgical Procedures0302 clinical medicineRobotic Surgical ProceduresInternal medicinerobotic surgerymedicineHumansRobotic surgeryeducationOvarian malignancygynecologic oncology; minimally invasive surgery; ovarian cancer; robotic surgery; Obstetrics and Gynecologyminimally invasive surgeryNeoplasm StagingRetrospective StudiesOvarian NeoplasmsCervical cancereducation.field_of_study030219 obstetrics & reproductive medicinebusiness.industryGeneral surgeryObstetrics and GynecologyGeneral MedicineEvidence-based medicinemedicine.diseasegynecologic oncology; minimally invasive surgery; ovarian cancer; robotic surgery; Case-Control Studies; Female; Gynecologic Surgical Procedures; Humans; Neoplasm Recurrence Local; Neoplasm Staging; Ovarian Neoplasms; Retrospective Studies; Robotic Surgical Procedures; Treatment OutcomeTreatment Outcomeovarian cancerSettore MED/40 - GINECOLOGIA E OSTETRICIACase-Control Studies030220 oncology & carcinogenesisFemaleNeoplasm Recurrence LocalbusinessOvarian cancer
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